Molecular pathways involved in H. pylori-induced apoptosis in epithelial cells, T cells, and macrophages are being dissected. The Vanderbilt Institute of Chemical Biology, 896 Preston Building, Nashville, TN 37232-6304, phone 866.303 VICB (8422), fax 615 936 3884 Vanderbilt University is committed to principles of equal opportunity and affirmative action. Leadership. Stahlman Chair in Infectious Diseases and Inflammation, Immunometabolism & Metabolic Diseases, Tumor Biology & Tumor Immunology, Human immunology, genetics, T cells, innate immunity, flow and mass cytometry, host-microbe interactions, microbiome, bioinformatics, GI pathology, epigenetic reprogramming, pancreatic cancer, Professor of Pathology, Microbiology & Immunology, DNA replication, mutagenesis, and evolution, Innate immunity initiated by activation of Toll-Like Receptor 3, next generation sequencing applications, pathogenesis of intracellular microbes, Immune regulation in autoimmunity and transplantation, Regulation of cell proliferation by growth factors, oncogenes, growth inhibitors and tumor suppressor genes, Estrogen, testosterone, sex hormones, T cells, innate lymphoid cells, asthma, allergy, Innate immune responses to bacterial pathogens in the lung, Mucosal immunology, IEL, iCD8alpha, osteopontin, granzyme, Pierre Soupart Chair in Obstetrics and Gynecology, Reproductive medicine, human endometium, endometrial dysfunction, endometriosis, progesterone action, Pathogenesis, helicobacter pylori, gastric cancer, carcinogenesis, infectious disease, bacterial pathogenesis, inflammation, malignancy, Molecular investigations of familial disorders, Lung, miRNA, exRNA (extracellular RNA), extracellular vesicles, allergy, asthma, Th2, Professor of Molecular Physiology & Biophysics, Cornelius Vanderbilt Chair in Immunobiology, T cell metabolism in inflammation and anti-tumor immunity, Amphibian immune defenses against an ancient fungal pathogen, Chair of the Department of Pathology, Microbiology and Immunology, Dorothy Beryl and Theodore R. Austin Chair in Pathology, Structure and biology of integrin adhesive receptors for extracellular matrix proteins, Clinical Microbiology, Molecular Diagnostics, Opportunistic pathogens, Microbe-microbe interactions, Personalized microbiology, Urinary tract infections, Jeffrey W. Mast Chair in Orthopaedics Trauma and Hip Surgery, The role of coagulation in normal and pathologic orthopaedic related wounds, Chair of the Department of Orthopaedic Surgery and Rehabilitation, Professor of Orthopaedic Surgery and Rehabilitation, Rehabilitation Dan Spengler, M.D., Chair in Orthopaedics, Proteomics of sarcomas, bone metastasis and tissue engineering, Assistant Professor of Medicine, Infectious Disease, Understanding host defense in pre-existing inflammatory conditions, Corneilius Vanderbilt Chair in Anesthesiology, Mechanisms of sepsis-induced systemic inflammation and organ injury with emphasis on the roles of natural killer (NK) and T lymphocytes, Director, Vanderbilt Institute for Infection, Immunology & Inflammation, Director, Division of Molecular Pathogenesis, Vice Chair for Research, Department of Pathology, Microbiology, and Immunology, Factors and processes involved in the battle for metal between bacterial pathogens and their hosts, Research Instructor Department of Pathology, Microbiology, and Immunology, Genomics, molecular biology, genetics and biochemistry of HIV-1 infection, Structural Biology of virulence factors, host-pathogen relationship, and cytoskeletal regulation, Director, CALDx - Center for Advanced Lab Diagnostics, Cancer, breast cancer, genomics, ChIP-seq, RNAseq, mutations, chromatin, transcription, epigenetics, Lipoprotein assembly, lipid droplet formation, adipocyte biology, Mechanisms that regulate immune tolerance and why they fail in autoimmune disorders such at type 1 diabetes, Role of innate-type regulatory lymphocytes in health and chronic inflammatory diseases, Research Associate Professor of Pathology, Microbiology and Immunology, Regulation of blood coagulation proteolytic enzymes, Translational research in acute lung injury and lung transplantation, Professor of Cell & Developmental Biology, Cancer invasion, membrane trafficking, cytoskeleton, systems biology, secreted exosomes, extracellular RNA, Molecular and immunologic mechanisms of thyroid cancer invasion and metastasis, Host immune response to the gastric pathogen Helicobacter pylori, Interactions between the immune and metabolic systems, whole body metabolism, Resilience mechanism of gut commensals, metabolic targeting of gut microbes to promote commensal resilience, and the roles of bacterial toxin in promoting colorectal cancer development, Associate Professor of Medicine, Hematology/Oncology, Associate Professor of Cell and Developmental Biology, Mechanisms by which normal and malignant cells regulate programed cell death or apoptosis following DNA damage, Copyright © 2020 Our laboratory investigates the structural basis for recognition, biochemical function and biological specificity of proteins and nucleic acids. By type. Mitochondrial dysfunction in neurodegeneration Mitochondrial dysfunction is an early event in the pathogenesis of neurodegenerative diseases. Molecular and Cellular Biology. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of congenital diaphragmatic hernia. Postdoc at Vanderbilt University Medical Center Nashville, Tennessee, ... working on understanding the molecular pathogenesis of the food-borne pathogen Campylobacter jejuni. Airway epithelial cells are prone to assault by risk factors and are considered to be the primary cell type involved in the field of cancerization. This complex contains five H. Ernest W. Goodpasture, MD, Award â For Groundbreaking Research that Addresses the Pathogenesis of Disease at the Cellular and/or Molecular Level John A. Oates, MD, Award â For Two or More Faculty Working Collaboratively or in a Multidisciplinary Manner to Address Important Biological Processes and/or Diseases Department of Biological Sciences, Vanderbilt University, Box 351634 Station B, Nashville, TN 37235-1634. The major focus of my research is to understand the interaction between host and pathogen during invasive bacterial infections. He earned his M.S. Professor, Departments of Chemistry and Biochemistry VICB Associate Director, Molecular Discovery Director, Vanderbilt Chemistry ⦠Director, Division of Molecular Pathogenesis. Brian O. Bachmann, Ph.D. More. /*-->cag T4SS core complex has an overall diameter and structural organization that differ considerably from the corresponding features of conjugative T4SSs. Some features of this site may not work without it. Postdoctoral Research - Vanderbilt University Medical Center. Author information: (1)Division of Molecular Pathogenesis, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Director, Institute for Infection, Immunology and Inflammation (VI4) Director, Division of Molecular Pathogenesis, Ernest W. Goodpasture Chair in Pathology, Ernest W. Goodpasture Chair in Pathology. [CDATA[/* >Helicobacter pylori cag T4SS, which has an important role in the pathogenesis of gastric cancer. High impact projects with strong preliminary data are currently available. As Co-PI of the Vanderbilt Center for Undiagnosed Diseases (VCUD), I provide oversight of the entire VCUD and development and implementation of all policies, procedures and processes including compliance with institutional, UDN and NIH policies. bacterial pathogenesis or virus replication), while imparting a knowledge of host biology sufficient for understanding pathogen-host interactions. Molecular Lung Cancer Screening In his research, Massion focuses on the development of molecular screening approaches to quantify the risk of lung cancer. Learn more about giving to the Libraries. Welcome. Specifically, we seek to define the bacterial virulence mechanisms and host defenses employed during osteomyelitis, an invasive infection ⦠Vanderbilt University Medical Center is committed to principles of equal opportunity and affirmative action. Bacterial type IV secretion systems (T4SSs) can function to export or import DNA, and can deliver effector proteins into a wide range of target cells. Negative stain single-particle electron microscopy revealed complexes 41 nm in diameter, characterized by a 19-nm-diameter central ring linked to an outer ring by spoke-like linkers. Home > Find Your Major > Molecular and Cellular Biology. To investigate risk-associated changes in the bronchial epithelium proteome that ⦠The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. Purpose. Neurodegeneration. ... Dr. Alexanderâs laboratory is focused on the role of adaptive immunity in the pathogenesis of hypertension and associated cardiovascular disease. Vanessa Sperandio, PhD Professor of Microbiology and Biochemistry University of Texas Southwestern Medical Center. Relatively little is known about the structural organization of T4SSs that secrete effector proteins. The Vanderbilt Center for Mucosal Inflammation and Cancer Seminar Series Keith T. Wilson, M.D. I also have a particular interest in evaluating novel molecular prognostic markers and studying the molecular pathogenesis of cancer as an integrated part of genetic epidemiology. Director, Vanderbilt Institute for Infection, Immunology, and Inflammation (VI4) Ernest W. Goodpasture Professor Vice Chair for Basic Research Chief, Division of Molecular Pathogenesis Vanderbilt University Medical Center. (2)Division of Pediatric Urology, Department of Urology, Vanderbilt University Medical Center, Nashville, TN ⦠A unique training program available to graduate students and postdoctoral fellows in the Biomedical Sciences at Vanderbilt University allowing for integration of thesis work with important clinical, disease-based areas. * { box-sizing: border-box; } .col-container { display: table; width: 100%; } .card { display: table-cell; padding: 16px; box-shadow: 0 4px 8px 0 rgba(0, 0, 0, 0.2); max-width: 200px; margin: auto; text-align: center; } @media only screen and (max-width: 600px) { .col { display: block; width: 100%; } } button { border: none; outline: 0; display: inline-block; padding: 8px; color: white; background-color: #000; text-align: center; cursor: pointer; width: 100%; font-size: 18px; } a { text-decoration: none; } button:hover, a:hover { opacity: 0.7; } John A. Phillips, III, MD. Dissecting the Molecular Pathogenesis of Bone Infection by Staphylococcus aureus. Incomplete complexes formed by Δcag3 or ΔcagT mutants retained the 19-nm-diameter ring but lack an organized outer ring. Seesandra V. Rajagopala, Ph.D., Associate Professor of Medicine Dr. Rajagopala is an Assistant Professor in the Department of Medicine at the Vanderbilt University Medical Center. Resources. in Biology from Bangalore University, India and his Ph.D. in Functional Genomics from the University of Heidelberg, Germany. pylori proteins, CagM, CagT, Cag3, CagX, and CagY, each of which is required for cag T4SS activity. JavaScript is disabled for your browser. Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Immunogold labeling studies confirmed that Cag3 is a peripheral component of the complex. The findings provide new insights into the sources of energy used by this complex molecular machine linked to the pathogenesis of gastric cancer. Explore scientific resources, protocols and other pages. The members listed below represent scientists and educators across the Vanderbilt community who are leaders in areas relevant to the mission of the Vanderbilt Microbiome Initiative. Biological sciences is a broad-based department, spanning molecules and cells, tissues and organisms, and populations and ecosystems. The molecular biology and immunopathogenesis of chronic inflammatory states, particularly sarcoidosis. Previous studies established that uropathogenic E. coli - the primary cause of urinary tract infections (UTIs) - can adhere to vaginal epithelial cells preceding UTI. Mechanisms of Bacterial Pathogenesis and Host Response Pathogenic bacteria have evolved a diverse array of mechanisms for delivering toxins and other virulence factors into the interior of host cells. CagX and CagY are orthologous to the VirB9 and VirB10 components of T4SSs in other bacterial species, and the other three Cag proteins are unique to H. pylori. ]]>*/, Professor of Pathology, Microbiology and Immunology, Cornelius Vanderbilt Chair in Pathology, Microbiology and Immunology, Biochemistry and molecular biology of HIV infection; Antiviral mechanisms, Associate Professor of Pathology, Microbiology and Immunology, Director, Division of Infectious Diseases, Addison B. Scoville Jr. The Lamb Center for Pediatric Research is an interdisciplinary research unit combining interests in infectious diseases, microbiology, and immunology. ... (e.g. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of congenital diaphragmatic hernia. pylori cag T4SS that are optimized for function in the human gastric mucosal environment. Vice Chair for Research, Department of Pathology, Microbiology, and Immunology Factors and processes involved in the battle for metal between bacterial pathogens and their hosts Interested parties should send a cover letter and CV to benjamin.spiller@vanderbilt.edu Learn more about giving to the Libraries. The findings provide new insights into the sources of energy used by this complex molecular machine linked to the pathogenesis of gastric cancer. The Center, established in 1990 through the generous support of Mr. and Mrs. George C. Lamb, Jr., is dedicated to basic research in the molecular pathogenesis of pediatric infectious diseases. He continued his formal training by completing a Postdoctoral Fellowship in Prokaryotic Systems Biology with an emphasis on protein interaction networks at The Institute for Geno⦠EOE/AA/Women/Minority/Vets/Disabled, Department of Pathology, Microbiology and Immunology, About the Division of Molecular Pathogenesis, Pathology, Microbiology and Immunology Faculty. Relatively little is known about the structural organization of T4SSs that secrete effector proteins. Creative Data Solutions (CDS) is a Vanderbilt Shared Resource and has extensive experience in providing effective and robust solutions to challenges pertaining to research data using modern informatics and bioinformatics approaches. Provided by Vanderbilt University. My current research interests are molecular investigations of the pathogenesis and treatment of Mendelian disorders. Issues with this site? Vanderbilt researchers are at the forefront of a golden age in biomedical science . In this thesis, I describe the isolation and analysis of a membrane-spanning core complex from the Helicobacter pylori cag T4SS, which has an important role in the pathogenesis of gastric cancer. We employ a diverse set of approaches to study pathogenesis, but a focus involves structural studies of relevant pathogen or host proteins. Reduced ATP levels, increased reactive oxygen species (ROS), impaired calcium buffering, and altered mitochondrial permeability are characteristic mitochondrial defects (Lin & Beal, 2006) . New roles in pathogenesis have been recognized for vacuolating toxin A (VacA) and urease, H. pylori membrane and secreted factors, and host epithelial surface molecules. Audrey Thomas Molecular Pathogenesis Research Assisstant at Vanderbilt University Medical Center Nashville, Tennessee 375 connections Director, Vanderbilt Institute for Infection, Immunology & Inflammation. These results highlight specialized features of the H. 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